Brand Name

Not specified

Dosage Form



Not specified


Not specified

Conditions Studied

  • Drug batches from stocks in central distribution facilities were sampled and retained
  • In outlying clinics, samples were taken of:
    • the oldest batch of each drug: intended to reveal degradation if the drug was unstable
    • batches of drug with the same lot number as those in the central distribution facility: intended to reveal changes in stability over time when compared with samples from the central facility

Temperature (degrees Celsius)

Not specified

Humidity (%)

Not specified

Countries Studied In

Harare and Bulawayo, Zimbabwe

Definition of Stability

Meet British Pharmacopeia specifications for potency (92.5-110% of stated)

Conclusions and Length of Stability
  • Manufacturers' stated shelf life: 2-3 years, depending on manufacturer (4 manufacturers included in study)
  • All central facility samples (79/79) were within British Pharmacopeia specifications at mean age of 17.5 months
  • No loss of potency observed in 39 central facility/outlying clinic pairs (samples with matched lot numbers) after a mean duration of 6.9 months
  • No indication of instability, even towards the end of shelf-life
  • Author's conclusions: aspirin tablets are stable under the conditions studied in Zimbabwe


Nazerali H, Muchemwa T, Hogerzeil HV. Stability of essential drugs in tropical climates: Zimbabwe. World Health Organization Action Programme on Essential Drugs. Accessed August 3, 2010 at:

MeSH entry terms
  • Acetylsalicylic Acid
  • Acid, Acetylsalicylic
  • 2-(Acetyloxy)benzoic Acid
  • Acylpyrin
  • Aloxiprimum
  • Colfarit
  • Dispril
  • Easprin
  • Ecotrin
  • Endosprin
  • Magnecyl
  • Micristin
  • Polopirin
  • Polopiryna
  • Solprin
  • Solupsan
  • Zorprin
  • Acetysal
MeSH reference:

Written by: Alex Evans, PharmD
Reviewed by:
Last updated: May 5, 2013