Brand Name
Not specified

Dosage Form



Not specified


Not specified

Conditions Studied

  • Eleven drugs were selected for study, and samples were taken for: 1) control pack and a 2) transported or test pack
  • Products in the test and control packs were taken from the same batch and were taken out of usual Unicef stock
  • Three sea routes, that represent regular routes for transportation of Unicef drugs (at the time of publication), were chosen:
    • Copenhagen, Denmark to Lagos, Nigeria: shipment took 51 days
    • Mombasa, Kenya to Kampala, Uganda: shipment took 52 days
    • Mombasa, Kenya to Bangkok, Thailand: shipment took 27 days
  • Temperature and humidity was auto-logged during shipment of four test packs (located in varying locations on the boat) and upon arrival test packs were shipped by air back to Sweden for analysis
  • Test packs from Bangkok were mistakenly shipped by surface mail and thus the drugs were excluded from analysis, although the climactic data was included

Temperature (degrees Celsius)
(given as a range during shipment)
  • Copenhagen to Lagos: -3.5 to 33.6
  • Mombasa to Kamapala: -2.3 to 42.4
  • Mombasa to Bangkok: 1.9 to 37.5

Humidity (%)


Countries Studied In

Denmark, Kenya, Uganda, Nigeria, Thailand

Definition of Stability

Not specified - data presented as percentage of active ingredient compared with stated amount.

Conclusions and Length of Stability
(parentheses are 95% confidence interval)

  • Control pack: 100.0 (99.9-100.2)
  • Test pack: 100.2 (99.7-100.8)

No statistically significant difference in potency between control and test packs


Hogerzeil HV, Battersby A, Srdanovic, Stjernstrom NE. Stability of essential drugs during shipment to the tropics. British Medical Journal 1992;304:210-4. Available at:
MeSH entry terms
  • Acetylsalicylic Acid
  • Acid, Acetylsalicylic
  • 2-(Acetyloxy)benzoic Acid
  • Acylpyrin
  • Aloxiprimum
  • Colfarit
  • Dispril
  • Easprin
  • Ecotrin
  • Endosprin
  • Magnecyl
  • Micristin
  • Polopirin
  • Polopiryna
  • Solprin
  • Solupsan
  • Zorprin
  • Acetysal
MeSH reference:

Written by: Alex Evans, PharmD
Reviewed by:
Last updated: May 5, 2013