Brand Name


Not specified

Dosage Form


Not specified

Strength

Not specified
Manufacturer

Not specified

Conditions Studied
  • Medication was protected from light
  • Procedure A: 30 days at 50 degrees C and 100% relative humidity
  • Procedure B: 30 days at 50 degrees C and 100% relative humidity followed by 5 days at 70 degrees C and 100% relative humidity
Temperature (degrees Celsius)

50, 70
Humidity (%)

100
Countries Studied In

Not applicable (lab experiment)

Definition of Stability

  • A standard for a degraded sample was created that contained 10% degradation products and 90% of the label.
  • This standard was used to compare to the tested product during analytical testing.

Conclusions and Length of Stability
  • The substance, originally in the form of white or slightly yellowish granules or a powder, changes after procedures A and B into a yellowish powder and the formation of needles is observed.
  • After procedures A and B there was 15% degradation. The degradation product was identified as theophylline.
  • Author's conclusions: Aminophylline is subject to decomposition under accelerated degradation conditions.

Reference


http://apps.who.int/medicinedocs/en/d/Jh1808e/


MeSH Entry Terms
  • Theophylline Ethylenediamine
  • Ethylenediamine, Theophylline
  • Theophyllamine
  • Aminodur
  • Key Brand of Aminophylline
  • Berlex Brand of Aminophylline
  • Aminophyllin
  • Searle Brand of Aminophylline
  • OPW Brand of Aminophylline
  • Aminophylline DF
  • Interstate Drug Exchange Brand of Aminophylline
  • Schein Brand of Aminophylline
  • Roxanne Brand of Aminophylline
  • Rugby Brand of Aminophylline
  • Barre Brand of Aminophylline
  • Major Brand of Aminophylline
  • Cardophyllin
  • Hamilton Brand of Aminophylline
  • Clonofilin
  • Clonmel Brand of Aminophylline
  • Corophyllin
  • SmithKline Beecham Brand of Aminophylline
  • Diaphyllin
  • Drafilyn
  • Zafiro Brand of Aminophylline
  • Duraphyllin
  • Durachemie Brand of Aminophylline
  • Eufilina
  • Euphyllin
  • Byk Brand of Aminophylline
  • Eufilina Venosa
  • Elmuquimica Brand of Aminophylline
  • Euphyllin Retard
  • Euphylline
  • Godafilin
  • Merck Brand of Aminophylline
  • Mini-Lix
  • Ferndale Brand of Aminophylline
  • Mundiphyllin Retard
  • Novophyllin
  • Phyllocontin
  • Purdue Frederick Brand of Aminophylline
  • Napp Brand of Aminophylline
  • Phyllotemp
  • Mundiphyllin
  • Mundipharma Brand of Aminophylline
  • Somophyllin
  • Tari-Dog
  • TVM Brand of Aminophylline
  • Theophyllamin Jenapharm
  • Jenapharm Brand of Aminophylline
  • Theophyllin EDA-ratiopharm
  • Theophyllin EDA ratiopharm
  • Theophyllin EDAratiopharm
  • ratiopharm Brand of Aminophylline
  • Truphylline
  • G and W Brand of Aminophylline
  • United Research Brand of Aminophylline
  • Afonilum
  • Knoll Brand of Aminophylline
  • Carine
MeSH Reference: http://www.ncbi.nlm.nih.gov/mesh/68000628

Written by: Alex Evans, PharmD
Reviewed by:
Last updated: June 10, 2013