Brand Name


Not specified
Dosage Form

Not specified

Strength

Not specified

Manufacturer

Not specified

Conditions Studied

  • Medication was protected from light
  • Procedure A1: 1 day exposure at 50 degrees C and 100% relative humidity
  • Procedure A2: 10 days exposure at 50 degrees C and 100% relative humidity
  • Procedure A3: 17 days exposure at 50 degrees C and 100% relative humidity
  • Procedure B: 30 days exposure at 50 degrees C and 100% relative humidity followed by 2 days at 70 degrees C and 100% relative humidity

Temperature (degrees Celsius)

50, 70

Humidity (%)

100

Countries Studied In

Not applicable (laboratory experiment)

Definition of Stability

  • A standard for a degraded sample was created that contained 10% degradation products and 90% of the label.
  • This standard was used to compare to the tested product during analytical testing.

Conclusions and Length of Stability

  • The substance, originally in the form of a white, crystalline powder, changes after procedures A and B into a colorless liquid.
  • Gain of moisture:
    • After procedure A1: 5%
    • After procedure A2: 40%
    • After procedure A3: 65%
    • After procedure B: 70%
  • Degradation:
    • After procedure A2: 60% of label
    • After procedure A3: 35% of label
    • After procedure B: 30% of label
  • Author's conclusions: Ammonium chloride is very hygroscopic and is subject to fast decomposition under accelerated degradation conditions.

Reference
http://apps.who.int/medicinedocs/en/d/Jh1808e/

MeSH Entry Terms
  • Chloride, Ammonium
  • Sal Ammoniac
  • Ammoniac, Sal
MeSH Entry Terms: http://www.ncbi.nlm.nih.gov/mesh/68000643

Written by: Alex Evans, PharmD
Reviewed by:
Last updated: June 10, 2013