Brand Name

Not specified

Dosage Form

Capsule

Strength

Not specified

Manufacturer

Not specified

Conditions Studied

  • Eleven drugs were selected for study, and samples were taken for: 1) control pack and a 2) transported or test pack
  • Products in the test and control packs were taken from the same batch and were taken out of usual Unicef stock
  • Three sea routes, that represent regular routes for transportation of Unicef drugs (at the time of publication), were chosen:
    • Copenhagen, Denmark to Lagos, Nigeria: shipment took 51 days
    • Mombasa, Kenya to Kampala, Uganda: shipment took 52 days
    • Mombasa, Kenya to Bangkok, Thailand: shipment took 27 days

  • Temperature and humidity was auto-logged during shipment of four test packs (located in varying locations on the boat) and upon arrival test packs were shipped by air back to Sweden for analysis
  • Test packs from Bangkok were mistakenly shipped by surface mail and thus the drugs were excluded from analysis, although the climactic data was included

Temperature (degrees Celsius)
(given as a range during shipment)
  • Copenhagen to Lagos: -3.5 to 33.6
  • Mombasa to Kamapala: -2.3 to 42.4
  • Mombasa to Bangkok: 1.9 to 37.5

Humidity (%)

20-88

Countries Studied In

Denmark, Kenya, Uganda, Nigeria, Thailand

Definition of Stability

Not specified - data presented as percentage of active ingredient compared with stated amount.

Conclusions and Length of Stability
(parentheses are 95% confidence interval)

  • Control pack: 96.4 (92.5-100.3)
  • Test pack: 96.1 (95.8-96.4)

No statistically significant difference in potency between control and test packs

Reference

Hogerzeil HV, Battersby A, Srdanovic, Stjernstrom NE. Stability of essential drugs during shipment to the tropics. British Medical Journal 1992;304:210-4. Available at:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1881477/pdf/bmj00057-0020.pdf

MeSH Entry Terms
  • Aminobenzylpenicillin
  • Penicillin, Aminobenzyl
  • Aminobenzyl Penicillin
  • Ampicillin Sodium
  • Sodium, Ampicillin
  • Ampicillin Trihydrate
  • Trihydrate, Ampicillin
  • Antibiotic KS-R1
  • Antibiotic KS R1
  • KS-R1, Antibiotic
  • Pentrexyl
  • Polycillin
  • Ukapen
  • Amcill
  • Omnipen
MeSH Reference: http://www.ncbi.nlm.nih.gov/mesh/68000667

Written by: Alex Evans, PharmD
Reviewed by:
Last updated: