Brand Name

Not specified

Dosage Form

Oral capsule

Strength

Not specified

Manufacturer

  • Medicines were shipped from an established supplier in the Netherlands to the Nile Province Essential Drug Project in Sudan in May 1989
  • Containers arrived in July 1989 in Port Sudan and were not climate-controlled, with temperatures frequently reaching above 50 degrees Celsius in the first three months of storage
  • Medicines were distributed in February 1990, and samples were taken in August 1990 and compared to batch samples kept by the supplier

Temperature (degrees Celsius)

  • Frequently above 50
  • No climate control was maintained

Humidity (%)

Not specified

Countries Studied In

Sudan

Definition of Stability

Not specified. Potency was compared between batches stored by the supplier and batches samples in-field.

Conclusions and Length of Stability

  • Potency:
    • Supplier: 97.2%
    • In-field: 94.6
  • Author's conclusions: Ampicillin trihydrate capsules did not show signs of instability under the conditions studied



Reference

Hogerzeil HV, De Goeje MJ, Abu-Reid, IO. Stability of essential drugs in Sudan. Lancet 1991; 338: 754-755.

MeSH Entry Terms
  • Aminobenzylpenicillin
  • Penicillin, Aminobenzyl
  • Aminobenzyl Penicillin
  • Ampicillin Sodium
  • Sodium, Ampicillin
  • Ampicillin Trihydrate
  • Trihydrate, Ampicillin
  • Antibiotic KS-R1
  • Antibiotic KS R1
  • KS-R1, Antibiotic
  • Pentrexyl
  • Polycillin
  • Ukapen
  • Amcill
  • Omnipen
MeSH Reference: http://www.ncbi.nlm.nih.gov/mesh/68000667
Written by: Alex Evans, PharmD
Reviewed by: